Reversible Mode Switching in Y coupled Terahertz Lasers

Electrically independent terahertz (THz) quantum cascade lasers (QCLs) are optically coupled in a Y configuration. Dual frequency, electronically switchable emission is achieved in one QCL using an aperiodic grating, designed using computer-generated hologram techniques, incorporated directly into the QCL waveguide by focussed ion beam milling. Multi-moded emission around 2.9 THz is inhibited, lasing instead occurring at switchable grating-selected frequencies of 2.88 and 2.92 THz. This photonic control and switching behaviour is selectively and reversibly transferred to the second, unmodified QCL via evanescent mode coupling, without the transfer of the inherent grating losses

Y coupled terahertz quantum cascade lasers

Here we demonstrate a Y coupled terahertz (THz) quantum cascade laser (QCL) system. The two THz QCLs working around 2.85 THz are driven by independent electrical pulsers. Total peak THz output power of the Y system, with both arms being driven synchronously, is found to be more than the linear sum of the peak powers from the individual arms; 10.4 mW compared with 9.6 mW (4.7 mW + 4.9 mW). Furthermore, we demonstrate that the emission spectra of this coupled system are significantly different to that of either arm alone, or to the linear combination of their individual spectra.Comment: 9 pages, 3 figure

The effects of linkage disequilibrium in large scale SNP datasets for MDR

<p>Abstract</p> <p>Background</p> <p>In the analysis of large-scale genomic datasets, an important consideration is the power of analytical methods to identify accurate predictive models of disease. When trying to assess sensitivity from such analytical methods, a confounding factor up to this point has been the presence of linkage disequilibrium (LD). In this study, we examined the effect of LD on the sensitivity of the Multifactor Dimensionality Reduction (MDR) software package.</p> <p>Results</p> <p>Four relative amounts of LD were simulated in multiple one- and two-locus scenarios for which the position of the functional SNP(s) within LD blocks varied. Simulated data was analyzed with MDR to determine the sensitivity of the method in different contexts, where the sensitivity of the method was gauged as the number of times out of 100 that the method identifies the correct one- or two-locus model as the best overall model. As the amount of LD increases, the sensitivity of MDR to detect the correct functional SNP drops but the sensitivity to detect the disease signal and find an indirect association increases.</p> <p>Conclusions</p> <p>Higher levels of LD begin to confound the MDR algorithm and lead to a drop in sensitivity with respect to the identification of a direct association; it does not, however, affect the ability to detect indirect association. Careful examination of the solution models generated by MDR reveals that MDR can identify loci in the correct LD block; though it is not always the functional SNP. As such, the results of MDR analysis in datasets with LD should be carefully examined to consider the underlying LD structure of the dataset.</p

Multiple electron pumping

The need to pump single electrons with a high degree of accuracy and fidelity has led to the development of a range of different pump and turnstile designs. Previous pumping mechanisms have all demonstrated that pumping more than one electron per cycle degrades the quantisation of the measured current. This unreliable delivery of multiple electrons per cycle has limited the use of on-demand single electron sources in electron quantum optic experiments. We present highly quantised current with multiple electrons pumped per cycle. We experimentally demonstrate that in our pumps an increase in electron throughput per cycle does not lead to an appreciable degradation in the accuracy of the produced current. Our pump is realised in an aluminium gallium arsenide two-dimensional electron gas, where electrons are pumped through a one-dimensional split-gate confinement potential under the influence of an applied source-drain voltage VSD , and where the pump is driven by a trapezoidal arbitrary waveform. This combination of a split-gate potential, VSD bias and trapezoidal wave form has led to the observation of robust quantised plateaus where not just a single electron, but a multiple integer number of electrons are pumped per cycle with a high degree of robustness and without the need of a magnetic field. For seven electrons per cycle, we report an increase of over two orders of magnitude in pumping accuracy from 2.72 × 10 − 2 in devices operating in the conventional pumping regime, to 1.64 × 10 − 4 in pumps operating in what we call the long plateau regime, a regime accessed under a change in a split-gate pumps applied VSD voltage. This pump will find direct use in quantum transport measurements where the metrological accuracy of single electrons pumped per cycle is not required and the low throughput per cycle of electrons is limiting

A unified potential drop calibration function for common crack growth specimens

Calibration functions, used to determine crack extension from potential drop measurements, are not readily available for many common crack growth specimen types. This restricts testing to a limited number of specimen types, typically resulting in overly conservative material properties being used in residual life assessments. This paper presents a unified calibration function which can be applied to all common crack growth specimen types, mitigating this problem and avoiding the significant costs associated with the current conservative approach. Using finite element analysis, it has been demonstrated that Johnson’s calibration function can be applied to the seven most common crack growth specimen types: C(T), SEN(T), SEN(B), M(T), DEN(T), CS(T) and DC(T). A parametric study has been used to determine the optimum configuration of electrical current inputs and PD probes. Using the suggested configurations, the error in the measurement of crack extension is <6% for all specimen types, which is relatively small compared to other sources of error commonly associated with the potential drop technique

Longitudinal Computer Generated Holograms for Digital Frequency Control in Electronically Tunable Terahertz Lasers

A transverse computer-generated hologram (CGH) diffracts and provides flexible control of incident light by steering it to any point in the projected image plane - i.e. CGHs are able to direct the light to where it is needed and away from where it is not. In addition, the number of resolvable points in the image projection plane is a function of the CGH's pixel count. Here we report a longitudinal CGH (LCGH), a photonic structure, which swaps the ability to steer light toward fixed spatial points for digital control in the frequency domain. This is of particular interest in the context of tunable lasers. In this regard, an LCGH offers two important degrees-of-freedom (DOFs): 1) provides high-resolution wavevector or k space resolution within the Brillouin zone; 2) enables full control to define or modify the reflectivity at each resolvable k point, so attaining a target spectral response. We demonstrate the flexibility of our LCGH approach by achieving purely electronic tuning between six digitally-selected operating frequencies in a single section terahertz (THz) quantum cascade laser (QCL). These switchable single-frequency devices will simplify combining the power and flexibility of THz QCLs with spectroscopic applications, such as remote sensing, spectral analysis, and both security and medical imaging.Comment: 17 pages, 4 Figures, submitted to Nature Photonic

Genetics of height and risk of atrial fibrillation: A Mendelian randomization study.

BACKGROUND: Observational studies have identified height as a strong risk factor for atrial fibrillation, but this finding may be limited by residual confounding. We aimed to examine genetic variation in height within the Mendelian randomization (MR) framework to determine whether height has a causal effect on risk of atrial fibrillation. METHODS AND FINDINGS: In summary-level analyses, MR was performed using summary statistics from genome-wide association studies of height (GIANT/UK Biobank; 693,529 individuals) and atrial fibrillation (AFGen; 65,446 cases and 522,744 controls), finding that each 1-SD increase in genetically predicted height increased the odds of atrial fibrillation (odds ratio [OR] 1.34; 95% CI 1.29 to 1.40; p = 5 × 10-42). This result remained consistent in sensitivity analyses with MR methods that make different assumptions about the presence of pleiotropy, and when accounting for the effects of traditional cardiovascular risk factors on atrial fibrillation. Individual-level phenome-wide association studies of height and a height genetic risk score were performed among 6,567 European-ancestry participants of the Penn Medicine Biobank (median age at enrollment 63 years, interquartile range 55-72; 38% female; recruitment 2008-2015), confirming prior observational associations between height and atrial fibrillation. Individual-level MR confirmed that each 1-SD increase in height increased the odds of atrial fibrillation, including adjustment for clinical and echocardiographic confounders (OR 1.89; 95% CI 1.50 to 2.40; p = 0.007). The main limitations of this study include potential bias from pleiotropic effects of genetic variants, and lack of generalizability of individual-level findings to non-European populations. CONCLUSIONS: In this study, we observed evidence that height is likely a positive causal risk factor for atrial fibrillation. Further study is needed to determine whether risk prediction tools including height or anthropometric risk factors can be used to improve screening and primary prevention of atrial fibrillation, and whether biological pathways involved in height may offer new targets for treatment of atrial fibrillation